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KMID : 0363320110320030425
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Journal of Korean Oriental Internal Medicine
2011 Volume.32 No. 3 p.425 ~ p.434
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The Effects of Morinda Officinalis Radix on Thyroid function in Hypothyroidism Rat Model induced by 6-propyl, 2-thiouracil (PTU)
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Kim Young-Seok
Ahn Se-Young
Ahn Young-Min
Lee Byung-Cheol
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Abstract
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Objectives: Hypothyroidism is the most common pathological disease of the endocrine system. Morinda Officinalis Radix has been used in treatment of Yang deficiency. In this study, we investigated the therapeutic effects of Morinda Officinalis Radix on a rat model of hypothyroidism induced by 6-propyl, 2-thiouracil (PTU).
Methods: Two-month-old Sprague-Dawley male rats were used with injection of PTU which induced rats into hypo-thyroidism. During 2 weeks, rats were treated with Morinda Officinalis Radix and thyroxine. Body weights were checked every week, the after 4 weeks, biochemical analyses were performed. The levels of T3, T4 and TSH was measured by EILSA.
Results: In the Morinda Officinalis Radix group, we could observe the level of T4 significantly increased and TSH level significantly decreased.
Conclusions: Morinda Officinalis Radix could help the thyroid to produce thyroid hormones under PTU suppression. There is no harm effect on liver and kidney function, or other metabolism. According to these results it could help to treat hypothyroidism patients and relieve their symptoms.
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KEYWORD
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Morinda Officinalis Radix, hypothyroidism, PTU, rat model
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